roles of beta arrestin dependent recruitment of src kinases in gpcr signaling
| PAG Title | roles of beta arrestin dependent recruitment of src kinases in gpcr signaling |
| PAG ID | WAG001010 |
| Type | P |
| Source Link |  BioCarta |
| Publication Reference | NA |
| PAG Description | The binding of ?arrestins to agonist-occupied GPCRs coincides with the recruitment of Src family tyrosine kises, including c-Src, Hck and c-Fgr (Src-TK), to the receptor?arrestin complex. Several sigling events have been reported to involve ?arrestin-dependent Src recruitment. These include the regulation of clathrin-dependent ?-adrenergic receptor endocytosis by tyrosine phosphorylation of dymin, Ras-dependent activation of the ERK1/2 MAP kise cascade and stimulation of cell proliferation by ?-adrenergic and neurokinin NK1 receptors, and stimulation of chemokine CXCR1 receptor-mediated neutrophil degranulation |
| Species | Homo sapiens |
| Quality Metric Scores | nCoCo Score: 1,369 |
| Information Content | Rich |
| Other IDs | |
| Base PAG ID | WAG001010 |
| Human Phenotyte Annotation | |
| Curator | PAGER curation team |
| Curator Contact | PAGER-contact@googlegroups.com |
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